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Material Safety Data Sheet: Bifendate

Identification

Product name: Bifendate
Chemical formula: C24H20O9
Synonyms: Dimethyl diphenyl bicarboxylate, DDB
CAS Number: 73536-69-3
Molecular Weight: 436.41 g/mol
Recommended use: Pharmaceutical ingredient for liver-related therapies
Manufacturing company contact: [Company details]
Emergency phone: [Local emergency medical number or chemical spill hotline]
Address: [Company address]

Hazard Identification

Hazard classification: Not classified as hazardous under GHS
Physical hazards: Dust formation possible, potential slight respiratory irritation
Health hazards: Inhalation or ingestion can cause mild headaches, dizziness, or stomach discomfort in sensitive individuals
Environmental hazards: Low risk at usual laboratory and industrial concentrations; spills into large bodies of water may threaten aquatic organisms
Signal word: None required for consumer or lab use at ordinary concentrations
Pictograms: None mandated

Composition / Information on Ingredients

Bifendate: 98-100%
Impurities: Trace inorganic salts, less than 1%
Additives: No intentional additives for raw powdered material
Safety limits: Meets pharmaceutical purity requirements, batch tested for contaminants

First Aid Measures

Eye contact: Rinse thoroughly with water for at least 15 minutes; seek medical help if irritation continues
Skin contact: Wash with plenty of soap and water; remove contaminated clothing and wash before reuse
Inhalation: Move to fresh air immediately, monitor for persistent cough or breathing difficulty, seek medical attention if symptoms develop
Ingestion: Rinse mouth, drink water, do not induce vomiting, get professional medical attention in case of lasting symptoms

Fire-Fighting Measures

Suitable extinguishing media: Water spray, carbon dioxide, dry chemical powder, foam
Hazards from combustion: Emits carbon oxides, possibly irritating fumes
Protective equipment: Self-contained breathing apparatus and protective clothing strongly advised
Other information: Cool containers exposed to fire with water spray; avoid breathing dust and fume

Accidental Release Measures

Personal precautions: Wear gloves, eye protection, dust mask to prevent inhalation
Environmental precautions: Avoid discharge into drains or surface water
Cleanup methods: Collect with suitable tools without generating dust, place in container for approved disposal, ventilate area

Handling and Storage

Handling: Use in well-ventilated areas, avoid generating dust, keep containers tightly closed
Storage: Store in a cool, dry, well-ventilated space, temperature preferably below 25°C, keep away from incompatible materials like strong oxidizers
Incompatibilities: Strong acids, bases, oxidizing agents
Storage life: Stable for 3 years under sealed, dry conditions

Exposure Controls and Personal Protection

Engineering controls: Use local exhaust ventilation in large-scale handling
Personal protective equipment: Gloves made of nitrile or PVC, chemical splash goggles, lab coat or protective suit, dust mask for airborne particles
Hygiene measures: Wash hands thoroughly after handling, avoid eating or smoking near the product, remove contaminated clothing

Physical and Chemical Properties

Appearance: Odorless white or off-white powder
pH: Neutral in water
Melting point: 185-188°C
Boiling point: Not measurable for solid
Solubility: Slightly soluble in water, freely soluble in organic solvents like ethanol
Vapor pressure: Negligible at standard conditions
Partition coefficient (n-octanol/water): LogP 2.8 - 3.2
Other properties: Stable under standard lab and storage conditions, non-hygroscopic

Stability and Reactivity

Chemical stability: Stable in normal conditions of temperature and pressure
Reactivity: Not reactive under ordinary use
Hazardous reactions: No dangerous reactions reported under proper use
Decomposition products: Carbon oxides and minor irritants if heated to decomposition
Incompatible materials: Strong oxidizing agents, concentrated acids and bases

Toxicological Information

Acute toxicity: Animal studies show oral LD50 (rat) > 5000 mg/kg, low toxicity profile
Chronic exposure: No evidence of carcinogenicity, teratogenicity, or mutagenicity at typical exposure levels used in pharmaceuticals
Exposure symptoms: Transient nausea, headache, mild skin or eye irritation from dust in sensitive individuals
Routes of entry: Inhalation, ingestion, potential skin and eye contact
Allergic reactions: No reports of sensitization reaction in standard tests

Ecological Information

Aquatic toxicity: Low short-term toxicity in fish, daphnia, and algae (LC50 > 100 mg/L)
Persistence and degradability: Expected to break down gradually in soil and water, does not bioaccumulate
Bioaccumulation: No significant bioaccumulation observed in studies
Mobility: Limited mobility in soil, binds to organic matter

Disposal Considerations

Waste treatment methods: Dispose according to local, regional, and national regulations for non-hazardous chemical waste
Incineration: Suitable for high-temperature chemical incineration
Packaging disposal: Triple rinse containers, destroy or recycle as mandated by country-specific rules

Transport Information

UN number: Not regulated for transport
Transport hazard class: Not classified as dangerous goods
Packing group: Not applicable
Environmental hazards: No significant risk during usual transportation
Special precautions during transport: Store containers securely, prevent mechanical damage

Regulatory Information

Label requirements: Not required to bear hazard pictograms or GHS signal word
Chemical safety report: Not mandatory for this compound
International regulation: Not listed as a controlled or hazardous substance by major regulatory bodies (REACH, OSHA, IARC, EU directives)
Other safety considerations: Subject to good manufacturing practice requirements for pharmaceutical use